Guired

I stumbled across this YouTube clip with a live performance and I like the sound
of the guitar.

My question is, how do one make the sound?

To point out which sound I'm wondering about it appears at
0:15-0:21
0:41-0:56
1:52-2:15
3:12-3:35

Zaphod_Beeblebr

There's nothing really odd going on there at all: he's strumming some chords and then playing some single note stuff with some vibrato and maybe some microtonal bends to give it that slightly bluesier edge.

If you mean the thin-as-anything tone then it's all from the piezo pickup on that acoustic.

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Guired

I don't mean the general sound of the whole song, I mean the characteristic sound appearing
between these time codes.

0:15-0:21
0:41-0:56
1:52-2:15
3:12-3:35

It sounds like a metal spring or an effect used in old porn movies (so I've heard).

Do you have a clip with this technique where I can see the guitar player?

Zaphod_Beeblebr

The sound you're thinking of isn't due to technique, it's all about note choice and groove. There is nothing physically interesting about what he's doing at any point.

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llBlackenedll

It's exactly what Zaph said... plus they're doing quite a bit of muting for percussive effect (as in, lightly resting the fretting hand fingers over all the strings so that they do not ring out and strumming). They're using varying degrees of power (again for rhythmic effect) when they hit the strings which probably helps accentuate the sound you're talking about.

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ESP Horizon FR II (EMG) / Ibanez Prestige RG1570 (DiMarzio Crunch Lab & LiquiFire pickups)

This ain't no wobbly-headed doll caper.