UG Member
Join date: Jan 2011
432 IQ
My guitar is currently set up with .10-.46 D'Addario's, but was thinking of getting some slightly heavier strings. Will my guitar need to be set up again, or can I just throw them on as is?
Registered User
Join date: Sep 2012
24 IQ
If you go heavier or lighter, you'll need to set up string height, truss rod, and intonation, as well as pickup height if you wish.
Join date: Aug 2011
10 IQ
Need is only if you notice what the differences are, honestly. The intonation is going to be off and the neck may move a bit, but it's not necessarily going to need adjustment.

Yes, it should be setup, but don't avoid trying different strings because you think you would be required to get a setup. You may hate the gauge, then you would need another setup to go back. I have had guitars go stupid from a gauge change and others that never changed a bit other than intonation being slightly off.