Your tone might be effected somewhat due to the nut being changed but it's going to be hard to notice so I would say no, not really.

ESP Standard Eclipse I CTM VW
ESP LTD Deluxe H-1001
ESP LTD Deluxe Viper-1000 STBC
ESP Edwards E-EX-100STD
Warmoth Paulcaster "Tiger"
Tanglewood TW170 AS
Vox Tonelab ST
Blackstar HT-1R

Quote by Twisted Magnum
Not really...

Those Super Vee's sure are damn ugly though.

i don't think they're that bad looking really, the nuts a bit of a chunk like, but you cant beat American US chromed car part lookie likies! Depending on your strat a FR or kahler could look ridiculous, but then again the looks won't really matter if it sounds great.