Some people always place it first in the effect chain, but some place it after distortion/overdrive/Wah. Where do you think is best to put it?

I use the amp's natural distortion (Carvin 100W master tube series combo), and I switch between clean and distortion a lot, how would you set the CS-3 to get the best tone out of it?

Thank you ahead and appreciate your inputs.

Oh, one more thing, I probably need to get a noise gate, now that I have a CS-3, where would you put the noise gate?
BTW, here is my current set up, before adding the CS-3...

LP Custom -> Bad Horsie II Wah -> Ibanez Stereo Chorus -> Boss DD3 Digital Delay -> Carvin 100W tube amp