What do you guys think is the best order for my pedals to go in for the best sound?

I have the following:

BOSS Tuner
BOSS RV-5 Reverb
BOSS BF-3 Flanger
Electro Harmonix Echo #1
Electro Harmonix Little Big Muff Pi
Line 6 DL4
Line 6 Tone Core Verbzilla Reverb
BOSS Dynamic Wah AW-3
BOSS GE-7 Equaliser
MXR Distortion III

Thanks a lot, I use a Epiphone ES-335 Dot through a Fender Deluxe 30 Watt Tube Amp.

Put the tuner first, then the wah, then the big muff, then the distortion 3.
Then put everything else in the effects loop.
What's the advantage of the effects loop and how do I set it up as I'd rather just set them all up in one go?
The advantage of the effects loop is that modulation effects sound well, better. Why don't you just expariment and try putting different pedals in different places.