If I tune a set a D'addario 10-46 strings too drop C will they be to loose? what is a good gauge for this tuning?
That won't be mind-bogglingly horrible, but I would definitely go heavier if you play tight-riffing metal. Try 11's, or perhaps a hybrid set that fades from 9/10/11 or so on top to something heavier on the bottom.
I play 10-52 on a Jackson DXMGT not loose at all, so the 10's would work but get a heavier gauge for your thickest string
Ibanez GSA60
Jackson DXMGT
Schecter Hellraiser Tempest
Ibanez S470 DXQM
ESP LTD Deluxe EC-1000
Crate Halfstack and Crate 50W Tube Head
Boss MT-2, CH-1, CS-3, NS-2, & Cry Baby
Crate XT65R