#1
I play a Strat which I just recently put 10's onto. I did this because other guitars I've played with 10's made me feel like I was getting a better grip on the string for bends and pull-offs.

I had the guitar setup by a professional and I noticed that he set the action just a smidge higher than I had been used to when the guitar had 9 gauge strings. Ever since the change I'm noticing my hand had been wearing out after about an hour of playing. I never experience this before I made the string change.

Do you guys think I should just switch back to 9's or before I do that possibly try lowering the action a bit? Will my hand strengthen up over time and get used to it?

I have a Les Paul with 10's that I don't seem to have a problem with. Could that be because of the scale length?
#3
you'll get used to it, but if your hand starts to hurt while practicing, stop. in this case, no pain no gain does not apply.
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Quote by freedoms_stain
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Maybe shagging Mark Knopfler, but that's about it.
#4
Try lowering the action, see if you can get more comfy with it without getting too much fretbuzz