I'm trying to play along with my powertab and I do not get any volume. I have my speakers turned up and when I had powertab before my computer was wiped this file worked! Thanks for any help!
My Gear:
Jay Turser Warlock
Baraccuda Strat
Takamine EG523SC
Samick Acoustic
Vox AD50VT
Boss DS-1
Boss CS-3
Dunlop Crybaby Wah
go into the guyitar settings in powertab, and turn up the individual sounds in there; if that doesn't help, save your work (if you have to), and close powertab. then open it, THEN it should work; if not, uninstall and then reinstall, but don't open Powertab right away, turn off your computer, then turn it back on, THEN open Powertab.

trust me, it should work. its happened to me a few times.
Thats happened to me before also. Somehow I removed the guitar that was supposed to be playing. So check that the guitars are added when they are supposed to be.