yes but you would need to buy a new pickguard and read up on your strat wiriness. It's not that hard, but it can go wrong.
If you want a full sized humbucker, you would have to see under your pickguard if its routed for a bigger pickup in the spot you want to use. If it is, you can get another pickguard that is cut for a H-S-S configuration or dremel your existing pickguard. Or you can get rail pickups which are 2 thin rails to form a humbucker in the same size as a single coil.
Lefty Strat Copy w/ GFS Lil' killer rails + Crazy wiring
Lefty Kona Thinline Acoustic/Electric
Righty-to-Lefty Silvertone Bass
Righty-to-Lefty Memphis Short Scale Bass

Tascam US-428 USB Interface Mixer
Guitar Rig 3
what GeToChKn said.
You have to go over the 100 bucks depending on whether you get a second hand or new pickup.
Last edited by chiliwillifreak at Aug 19, 2009,
The last meaning the one closest to the bridge? Well, if you dont have the pickup you want to use, or a router, that could cost you over $100 right there. Getting it professionally done, along with the cost of the pickup and pickguard, it'll probably be over $100.