An Boss ME-70 as pre amp----Electro Harmonix 22W power amp-----Fender Hot rod Deluxe 80W Cab? Would that work, be loud enough for drums, and sound good for all genres of music?
I dont know, I do know that you cant throw more wattage into another amp without it being overloaded. Like if you have a 22 wate tube amp and you put 50 watts from another amp into it, it will blow a fuse, same thing the other way. I'm not sure though, and how did you get a fender hot rod delux cab? Dont they come with an amp, like built into the cab?

But 80 tube watts is more than enough to play with drums, if you can even get 50 tube watts thats still more than enough.