I have a MIM strat and was curious what are the top upgrades for them in improving sound and performance. I think mine was a 2003 or 04 model?
1. is a good amp.

2. are pickups, strings (gauge and style), pedals, technique...

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Set up Questions? ...Q & A Thread

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I always add graphite saddles and a roller string tree and lube the nut to start off with. Helps with any problems staying in tune and only costs about $30. After that pickups and wiring. By wiring I mean getting a tone control on that pesky bridge pickup.
I reckon you should get new:

Locking tuners
wiring maybe
and a professional set-up
New tremolo, not a locking one, just a good one.