#1
ive just replaced the bottom estring on my guitar and now it makes no noise when played througth an amp, what could be the problem
#2
Couple possibilities..

1. EQ/volume settings on guitar/amp/pedals
2. Pickup too low / too high / pole pieces not correctly alligned with the strings

2001 Ernie Ball Music Man Axis Super Sport
2001 MIM Standard Strat
Peavey Classic 30 112 Combo.
My Gear
#3
or your pickup or switch could have sh!t the bed...
My Gear:

Squier Stratocaster
Italia Maranello
Ibanez GIO
Samich D-1
Baldwin SG
Fender CD100CE

Proel WahWah
Digitech RP-80 Multi-Effects

Peavey Combo Amp
Marshall Practice Amp
#5
Did you use an acoustic guitar string?
A metal band?
Gear:
A Guitar with an LFR > Korg Pitchblack > Behringer EQ > Hardwire CM-2 Overdrive Boss SD-1 > Hardwire CR-7 Chorus>
Orange Tiny Terror >
LzR Engineering 212 cab

My other amp can run Crysis