There'd be less wood to resonate, for one.
Fender Highway 1 Strat
Agile Septor Pro 725

Fender Hot Rod Deluxe
Axe-Fx Ultra

Trust me, I'm a medical student
some people would say less wood means less sustain. Its up to your ear really.
*lust list*
Vox tone lab
Vox ac50
satches time machine
vintage phase 90
Money towards this gear = $0.00

Quote by Doctor Matthews
Yeah I dreamt I was fighting Master Hand, but then I woke up to realize I was jackin' it in my sleep.
1 - lrn2link. yours is messed up because of the )? you added. leave a space.

2 - Not all that a big problem structurally.

3 - What's left behind (the thin area between the pickup cavity and the trem cavity can sometimes resonate more freely. Sometimes for the better, sometimes for the worse.

4 - Less support for the pickguard is a significant issue. If it vibrates more freely, your pickups move, in relation to the strings. This is rarely a good thing.

5 - If you cut away only what's needed to provide a space for what you will use, not anything you might possibly use, you get more predictable results.
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I wont be like those jerks who dedicate their beliefs to logic and reaosn.