#1
Now i normally use a standard set .10 - .46, but because my band plays in drop D, should i be using a thicker "E" string such as a .52 for the "E" string to be dropped down to D?

I recently bought a set of Light Top/Heavy Bottom strings, will changing froma regular gauge to these make much of a differenceto my intonation and such?

(Regular set being .10, .13, .17, .26, .36, .46, to the Light Top/Heavy Bottom set being .10, .13, .17, .30, .42, .52)
#2
you would be fine using the regular guage, but a slightly thicker one wouldn't hurt either, but .52 is unnecessarily thick. if you can find something in between it would be best.
Hovercraft Falcon 100 "La Dama del Solaris"
ESP LTD Phoenix-1000
Epiphone Les Paul Custom Silverburst
#3
it shouldnt be to much of a difference intonation-wise. I use 10-52's in standard because they just feel more stable than lighter strings. try em out, i think youll like them too. Its just gonna take a little bit to get used to them