I'm helping a buddy of mine shop for amps, and he's interested in buying a Fender Hot Rod Deville. That amp comes in a 2x12 or a 4x10. What tonal difference would there be between the two? This is not a versus thread, but simply asking a question of tonality or sound from speaker arrangments.
Well if you go compare the freq specs for 10s and 12s. The 10s freq center will usually be higher than a 12. So a 12 will usually have a little better bass response at expense of the highs. Its not an absolute rule depending on speaker.

Then there is the difference between open back and closed back cabs. Dont know which the deville is.