#1
Does anyone know how to get the tone and sound of Nick Valensi?

I have a MIM Fender Telecaster, just wondering what pickups I should replace the stock ones with so I have a sound more like his.
#2
depends how much work you want. P-90's would be ideal but that would require some modification to your instrument. They're renowned for using hot rod deluxe amps and a visual sound jekyll and hyde overdrive pedal which are both relatively inexpensive pieces of kit. Be warned you'll only get near and not identical with a telecaster no matter what pickups are in it.