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#1
For pictures:
http://www.lazypalace.com/ageless-girl-syndrome-x/

Brooke Greenberg (born January 8, 1993), is a 17 year old girl from Reisterstown, Maryland, who has remained physically and cognitively similar to a toddler, despite her increasing age. She is about 30 inches (76 cm) tall, weighs about 16 pounds (7.3 kg), and has an estimated mental age of 9 months to 1 year. Brooke’s doctors have termed her condition Syndrome X.
Brooke was born on January 8, 1993 at Sinai Hospital in Baltimore, Maryland, one month prior to her due date, weighing just four pounds (1.8 kg). She was born with anterior hip dislocation, a condition which caused her legs to be swiveled upwards, awkwardly, toward her shoulders; this was corrected surgically. Otherwise, Brooke appeared to be a normal infant.
In her first six years, Brooke Greenberg went through a series of unexplained medical emergencies from which she recovered. She had seven perforated stomach ulcers. She also suffered a seizure. This was followed by what was later diagnosed as a stroke; weeks later, no damage was detected. At age five, Brooke had a mass in her brain that caused her to sleep for 14 days. The doctors diagnosed the mass as a brain tumor. However, Brooke later awoke, and physicians found no tumor present. Brooke’s pediatrician, Dr. Lawrence Pakula, states that the source of her sudden illness remains a mystery.
Over the past several years, the Greenbergs visited many specialists, looking for an explanation for their daughter’s strange condition, and found she has a mutation in Chromosome 1. In 2001, when Dateline documented Brooke, she was still the size of a six-month-old infant, weighing just 13 lb (5.9 kg) at 27 inches (69 cm) tall. The family still had no explanation. Brooke Greenberg’s mother Melanie said: “They [the specialists] just said she’ll catch up. Then we went to the nutritionist, the endocrinologist. We tried the growth hormone…”. The growth hormone treatment had no effect. Howard, Brooke’s father, said: “I mean she did not put on an ounce or she did not grow an inch … That’s when I knew there was a problem.” After the growth hormone administration failed, the doctors, unable to diagnose a known condition, named her condition Syndrome X.
The Greenbergs made many visits to nearby Johns Hopkins Children’s Center, and even took Brooke to New York’s Mount Sinai Hospital, searching for information about their daughter’s condition. When geneticists sequenced Greenberg’s DNA, they found that the genes associated with the premature aging diseases were normal, unlike the mutated versions in patients with Werner syndrome and progeria.
In 2006, Dr. Richard Walker of the University of South Florida College of Medicine, said that Brooke’s body is not developing as a coordinated unit, but as independent parts that are out of sync. She has never been diagnosed with any known genetic disorder or chromosomal abnormality that would help explain why.
In 2009, Walker said: “There’ve been very minimal changes in Brooke’s brain … Various parts of her body, rather than all being at the same stage, seem to be disconnected.” Walker noted that Greenberg’s brain, for example, is not much more mature than that of a newborn infant. He estimates her mental age at around 9 months to a year old. Brooke can make gestures and recognize sounds, but cannot speak. Her bones are like those of a ten-year-old, and she still has her baby teeth, which have an estimated developmental age of about 8 years. Said Walker, “We think that Brooke’s condition presents us with a unique opportunity to understand the process of aging.”
Her telomeres seem to be shortening at the normal rate.





She's a few months older than I am!
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#7
Quote by mrcrono
So she's almost legal


Come England, she is legal.
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#8
Quote by mrcrono
So she's almost legal



Which makes me wonder, would it be legal or her to be in porn in a few years time? It's not like she looks distinctly like a midget or anything, she just looks like a toddler.


I don't have time to read the article, but is she the same mentally as a 17 year old?

"The mind is its own place, and in itself

Can make a Heav'n of Hell, a Hell of Heav'n"

- John Milton, Paradise Lost
#10
I like how someone is possible immortal and the first thing the pit thinks about is her doing a porno, well done lads.
#11
Quote by josh999x
I like how someone is possible immortal and the first thing the pit thinks about is her doing a porno, well done lads.

Did you REALLY expect anything else?
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#13
Quote by metallicafan616
Which makes me wonder, would it be legal or her to be in porn in a few years time? It's not like she looks distinctly like a midget or anything, she just looks like a toddler.


I don't have time to read the article, but is she the same mentally as a 17 year old?

I watched something on TV about her, if I remember right, no. She's essentially still a baby
#14
Quote by josh999x
I like how someone is possible immortal and the first thing the pit thinks about is her doing a porno, well done lads.



I was thinking the same thing.
#16
Quote by josh999x
I like how someone is possible immortal and the first thing the pit thinks about is her doing a porno, well done lads.


I didn't say she should do porno, just wondering if it's illegal because she's basically a child and only paedophiles would watch it, so perhaps:

Quote by josh999x
I like how someone is possible immortal and the first thing the pit thinks about is doing her, well done lads.


And bloody hell, did it say she was possibly immortal/able to live longer than normal humans!?


Quote by TheSexPanthers
I watched something on TV about her, if I remember right, no. She's essentially still a baby


Thanks, and btw, your username fits perfectly with this post.

"The mind is its own place, and in itself

Can make a Heav'n of Hell, a Hell of Heav'n"

- John Milton, Paradise Lost
#17
Quote by metallicafan616


And bloody hell, did it say she was possibly immortal/able to live longer than normal humans!?

Well that's the astounding bit. They don't know. All they know is she has a mutation in Chromosome 1, but nothing more.
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#18
Does this mean she could live well past the normal human life expectancy?
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#19
Jesus christ.

To live forever all we have to do is mutate our children.

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#21
Quote by valennic
Jesus christ.

To live forever all we have to do is mutate our children.



Yeah, it might seem cruel, but they should freeze some of her cells just in case this is beneficial to the species and she's too selfish to give them away. Afterall, she's still a toddler at 17, so 17 / 4 = 4.25 , 4.25 * 18 = 76.5 which by my calculations means she will be at the end of puberty when she's 76.


EDIT: ^ LSD looks like so much fun.

"The mind is its own place, and in itself

Can make a Heav'n of Hell, a Hell of Heav'n"

- John Milton, Paradise Lost
Last edited by metallicafan616 at Jul 27, 2010,
#22
Quote by metallicafan616
Yeah, it might seem cruel, but they should freeze some of her cells just in case this is beneficial to the species and she's too selfish to give them away. Afterall, she's still a toddler at 17, so 17 / 4 = 4.25 , 4.25 * 18 = 76.5 which by my calculations means she will be at the end of puberty when she's 76.


So, if thats right, since on average people live to be about 70-80, this rate of growth means...she may be able to live to the age of 456. Effectively outliving everyone alive today. And for several generations afterwards.

But dont trust my math, since I suck at it.

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#23
Brb, going to smoke a spliff with my friend Peter Pan.
❝Don't be afraid of death, but of an inadequate life❞
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#24
Quote by valennic
So, if thats right, since on average people live to be about 70-80, this rate of growth means...she may be able to live to the age of 456. Effectively outliving everyone alive today. And for several generations afterwards.


The article did say she's had many stomach ulcers, seizures, and even slept for two weeks once because the doctors thought she had a tumour. I doubt health problems like that would allow her that much of a lifespan.
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#25
Quote by ledhead67
The article did say she's had many stomach ulcers, seizures, and even slept for two weeks once because the doctors thought she had a tumour. I doubt health problems like that would allow her that much of a lifespan.

Yeah I'm not sure where you guys are getting this immortality theory from. It's sounds like an almost adult woman who's been suffering with a growth deficiency her whole life.
#26
Quote by valennic
So, if thats right, since on average people live to be about 70-80, this rate of growth means...she may be able to live to the age of 456. Effectively outliving everyone alive today. And for several generations afterwards.

But dont trust my math, since I suck at it.
If you read the article it is clear that she is not a perfectly normal and healthy baby other than the fact that she is growing slowly. She had lots of serious medical emergencies (including a stroke) and different parts of her body are growing at different rates (her bones are 10 so when she is 456 they would be more than 228).

Sadly, I doubt she'll live as long as the average life expectancy, let alone longer.
#27
Quote by mrcrono
Yeah I'm not sure where you guys are getting this immortality theory from. It's sounds like an almost adult woman who's been suffering with a growth deficiency her whole life.

But it's not a growth deficiency that has EVER been seen before. It's both mental and physical. Her mental age is no more than a year, her bone age is about 11, her teeth age is about 8. It's amazing.
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#29
And there's also the fact that it says on the article that her telomeres are shortening at a normal rate. And telomeres are the parts in DNA responsible for mitosis, or cell division. Which means that when there's no longer telomeres, she won't have any new cells and will die of cancer or something like that.

http://en.wikipedia.org/wiki/Telomere

So sadly, she isn't immortal and will die like the rest of us, if not even faster.
Fight the evolution, play large intervals!
Last edited by Tupu at Jul 27, 2010,
#30
I have just gathered unfortunate news; Brooke Greenberg has died. In the early morning an unknown assailant wielding a large sword decapitated her. There is no known motive but the murderer was heard screaming "There can be only one" before brutally killing her.


Well, that wasn't very funny but someone had to make a Highlander joke.
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#32
Quote by blue sky noise
so... if her body isnt aging, and she doesnt have any life threatening medical conditions...she could live to be over 100+ years easily...thats amazing.

Even if her body doesn't age like the rest, it doesn't mean her cells wouldn't age. Read the post I had posted up there ^


Of course, she COULD live to 100+, but it's doubtful.
Fight the evolution, play large intervals!
Last edited by Tupu at Jul 27, 2010,
#33
Quote by valennic
So, if thats right, since on average people live to be about 70-80, this rate of growth means...she may be able to live to the age of 456. Effectively outliving everyone alive today. And for several generations afterwards.

But dont trust my math, since I suck at it.


8 * 0.25 = 2
8 * 4 = 32
10 ( 32 + 2 ) = 340


Anyway, quite disappointing that this isn't just ultra slow ageing, with her cells properly replicating like normal just for a longer time. So for instance, instead of her cells ability to replicate properly and not die off decreasing with old age at 50, at 212.5

"The mind is its own place, and in itself

Can make a Heav'n of Hell, a Hell of Heav'n"

- John Milton, Paradise Lost
Last edited by metallicafan616 at Jul 27, 2010,
#34
Quote by angusfan16
Does this mean she could live well past the normal human life expectancy?



No.
Thr article said her telomeres deteriorate at a normal rate.
http://en.wikipedia.org/wiki/Telomeres
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#35
Tupu, I think you failed Biology.... I see what you're getting at, but you're presenting two different theories at the same time.... if she doesn't have any new cells, yeah, she'd die. However, cancer is actually caused by rapid cell division; it causes the patient to have MORE cells than their body can support.

Still, both actually sound plausible.*

*Note: This is coming from a 15 year old; trust nothing.
#36
Quote by opc100
I've seen this before, ages ago.


As did I.

Quote by josh999x
I like how someone is possible immortal and the first thing the pit thinks about is her doing a porno, well done lads.


She isn't immortal, she'll just have the body and mind of a toddler throughout her life.
Although I am proud of the pit.
#37
Well, I've learnt something from this thread, thanks!

"The mind is its own place, and in itself

Can make a Heav'n of Hell, a Hell of Heav'n"

- John Milton, Paradise Lost
#38
Quote by herby190
Tupu, I think you failed Biology.... I see what you're getting at, but you're presenting two different theories at the same time.... if she doesn't have any new cells, yeah, she'd die. However, cancer is actually caused by rapid cell division; it causes the patient to have MORE cells than their body can support.

Still, both actually sound plausible.*

*Note: This is coming from a 15 year old; trust nothing.


I admit, I am not too good at biology, and haven't even dwelved too far into the telomeres. I admit, I am not too sure if cancer is caused by missing telomeres, but the fact is that after her telomeres are gone (or too short) she will die, because there will be no more new cells to replace the old ones. I think this is ageing in a biological sense, I could be wrong. And as cancer is also the result of cells dividing themselves abnormally, the telomeres do have their hand on cancers...


EDIT: I'm just seventeen and trying to recall what I remember of cell growth from my hich school lessons.
Fight the evolution, play large intervals!
Last edited by Tupu at Jul 27, 2010,
#39
Sorry, I guess I kind of overstepped myself. All I meant is that you're presenting two completely opposite theories on her death as one. See, if her cells don't divide, yes, she will die, because she will run out of cells. Cancer, however, is exactly the opposite. It's when the part of the cell that controls cell division is damaged, causing cells to rapidly divide. Instead of her dying from running out of cells, she'd die as a result of having more cells than her body can support.
#40
Yeah, I should have thought about it more before "correcting someone wrong on the internet"... But in the end she will die because her cells don't follow the slow growth of her outer parts.

EDIT: After reading a bit of it, I should have probably scrapped the whole "no more cells" thing and just went with the theorem that shortening of the telomeres causes ageing and cancer. Of course, citation needed (wikipedia :S)
Fight the evolution, play large intervals!
Last edited by Tupu at Jul 27, 2010,
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