For some reason, whenever I play past the 12th fret on my high e string, it sounds out of tune, but when I play lower, like near the 5th fret or whatever, it sounds fine, without adjusting the tuning at all. The rest of my guitar is in tune when this happens. Could someone please tell me how to fix it?
This means that your intonation is off on your guitar. This can cause your guitar to sound more out of tune the higher up you play.
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Quote by theogonia777
i fond God too, man! i sat next to him on the bus once. he told be the meaning of life and then gave me a pretzel. i can't remember what the meaning of live was, but it was a good pretzel, man!

Can you adjust the saddles on your bridge?
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^I'd let a pro look at it. Once you get into the technicalities of screws...well, it's just a place you don't want to be, friend.
Happened to me before, changed the strings and it was fine again.

Take a tuner, make the open string in tune, then pick the 12th fret. See if it's still in tune. If it's not you can adjust the saddle on the bridge.
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You have 2 options.

1. Tits.
2. GTFO.