K so i got my jackson kelly from japan.. sick guitar.. well i gave it a neck adjustment and floyd rose set up.. did a decent job.. BUT!!!

Realized to today that my 22nd fret D up whole setup to E has sub-par note sustain.. which none of the other frets in that area have.

I dont want to the truss rod the wrong way.. Im measuring 16th turn but in which direction?
My Gear:
JacksonStars KE TN-02
Jackson DK2M
Jackson WRXT
Jackson KSXT
Jackson DXMG
Jackson 7 String soloist

Ovation Celeberity
If its only a problem on one string, I'd be more inclined to check the frets. Yeah, you can tighten the rod a fraction and raise the bridge but that will cost you in terms of string height of the other strings.
I pick up my guitar and play
Just like Yesterday

T C Ellis Series 2 LP w/Skatterbrane Quiescence pups
Cort EVL-K6
Yamaha RGX211 modded
H&S Electric 12-string
Shaftsbury Ricki 4001
'84 Fender Yale
Roland Cube 15x

please use the setup thread sticky in electric guitar. a setup is not really a customization.

and as said, if its only a problem on one string, adjusting your neck is probably not the best solution.