#1
Specifically the clean settings I should have, and what should I have on the pedal itself (ex. tone, sustain and volume). Running the LBM through the front of a Peavey 112 Valveking. I'm also looking into trading out the stock speaker, Celestion perhaps? I want that British tone since Weezer apparently runs through VOX amps, and I usually play classic rock.
"When in doubt, listen to the Beatles."

Gear;
Peavey Valveking 112
Epiphone SG Standard w/ SD Pearly Gates bridge
#2
Weezer uses more "crunchy" distortion and since the LBM is more of a fuzz it will be difficult. Because the LBM also compresses the tone a lot and gives you extra bass you might want to turn the sustain knob down and the tone knob up for a more natural distorted sound.