When ever I try to tune up my low e string slips out of the saddle. How can I fix it?
You say it's a tremolo issue so...Well is the string cut long enough? Is the hex-nut that holds the string in tight enough?
The strings are new and I make sure to tighten it properly.
The little black plastic thing in the saddle could have cracked or worn away, which means a replacement will be needed (dont worry they're quite cheap). Take the black plastic bit out a try and clean out the inside of where it usually sits. This might help.