Well, because the acoustic is a louder instrument, you will probably still hear the physical, actual pitch of the strings as you play them, as well as the dropped pitch, that comes through the amp/PA.

I'd say its possible to do, but using a droptune on electric, when I can still barely hear the actual string pitch throws me off, so I can't imagine how annoying it would be, to be playing in standard, and hearing both that, and the same thing a step down, at the same time.