This is probably a silly question but would my Pod Studio sound much different through a set of KRK Rockit 5s versus cheap $50 Insignia desktop speakers?

Haha thanks.
What makes you wanna get these speakers? Based on the fact that you don't know there's a huge difference between a set of cheap desktop speakers and a pair of mid-end studio monitors, makes me think that you've only just heard about these things or only just started to record. Do you know they're for monitoring/recording purposes, not necessarily to listen music with / game with? Studio monitors are cool but they're flat (EQ-wise) so there's none of the overdriven epic bass and treble that you get in modern stereo speakers.

Of course if you're trying to make your recordings sound better, yes, these Rokits will be WAY WAY better than your Insignia speakers.