I am hooking up to a Fender Hot Rod Deluxe to a Fender single coil tele with some effects in between. Maybe I'm not use to the amp, but it keeps sounding like the tone is underwater. I want to make it a little more trebley, but simply moving up the treble dosent really help.

Any ideas??? Thanks guys and gals.

Simplest answer first: Check your toneknob?
Tell me who's that writin'...
How many effects do you have? If theres a lot or some of them aren't true bypass you can get some high end loss, you can try plugging in straight to your amp and see if that helps.
LTD F-50
Yamaha EG-112
'77 Harmony
Roadworn Starcaster
Gretsch G5120

Vypyr 15
Epiphone Valve Junior combo
Take all the pedals out, and just go Guitar > Amp.

Still have a problem? If yes, check the amp's tubes.
If no, then put in one effect at a time, trying each one individually.

What cables do you use?
Then there's this band called Slice The Cake...

Bunch of faggots putting random riffs together and calling it "progressive" deathcore.
Stupid name.
Probably picked "for teh lulz"

Mod in UG's Official Gain Whores