sorry for the stupid question, but is it possible to accent a note with an upstroke?

im working on new licks for alternate picking playing sextuplets starting on the high e and ending on the low e.

its 3 notes on the high e, 6 on the b, g, d, a strings and 3 on the low E. im starting with an upstroke because i am more confident with outside picking, but i have to end the lick with an upstroke.

any ideas?

I'm pretty sure it's not possible to accent notes with upstrokes..

edit: Ok I lied! You can accent notes with whatever really
Things with strings:
Ibanez J.Custom, Prestiges, RG8, SR5 bass etc
LP's, Strat, Tele
ENGL Retro Tube 50
5150 III 50W
Orange Terror Bass