I'm trying to play this in Hangar 18 by Megadeth.
is there an alternative to the 22nd fretted note. I don't have a 22 fret guitar
you could play it at the 17th fret on the E string or just bend up from the 21st (the tab does indicate a slide anyway so why not bend instead). You should have realised that if you play the B string at the fifth fret it is the same note as the open high E string.
But boys will be boys and girls have those eyes
that'll cut you to ribbons, sometimes
and all you can do is just wait by the moon
and bleed if it's what she says you ought to do