do you always need a pc to create/edit patches for ME-25. I heard, it requires a ME-edit software to do it?
No, you can create patches right on the unit. Read the manual on how to do it.
Guitars: Fender FSR Standard Strat, Squire Affinity Strat, Epiphone Nighthawk
Amps: Vox AC15C1, Roland Cube 15x, Peavey KB-1
Pedals: Digitech RP355, HD500, Joyo AC-Tone, EHX Soul Food