I was wondering, should the saddles be parallel to the bridge? I noticed that the saddles on my strats are a little sideways on my high E. Could this affect my guitar?
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level them and lower them (by raising the pegs) if you can get them lower and still be buzz free. (if you want lower action)

use a tiny allen wrench, on the front facing pegs.

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Set up Questions? ...Q & A Thread

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just that they're angled so that the intonation is spot on...
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