im about to buy a line 6 M5 tomorrow for the delays and silly effects, but I was wondering where I should put it in my setup. I run my guitar into an overdrive into my amp. so should I put it before the OD, after, or in the effects loop?
Schecter Blackjack SLS C-1 Active
Schecter Damien w/ Seymour Duncan Distortions
Peavey 6505+ 112
Blackstar HT-1RC
Visual Sound Double Trouble
Line 6 M-5
Broadly speaking, delayed distortion sounds good, distorted delays sound bad. So you'll definitely want it after the overdrive, and if you use amp distortion (which I assume you do, Mister 6505), you want it in the loop.

Might be worth experimenting with it both ways, though. You might be that one guy in a thousand who likes the tone better with the distortion first. There are no hard and fast rules here; you pick whichever sound you like.
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