I really think the start of this song sounds so cool (Megadeth- Lucretia ), but I can't seem to get the muting right on start of the strings. I don't know if it's because it's on 2 of the 3 highest strings and I have hands too big, but I just seem to mute the notes out completely wherever my hand is.

I can play the riff fine unplugged, but without the muting with distortion on the whole first part sounds wrong, there's no clarity with the notes and they bleed into one mess.

Any help would be greatly appreciated.

P.S, I know how to palm mute and I'm fine at it on the lower strings, I just can't seem to transfer it further up.
[Gibson Explorer]
[Ibanez RG1XXV]
[Line6 PodHD]
[ENGL Retro Tube 100]
[Dunlop CryBaby]