I've used stomp box distortion all my life. I have a mesa and love the dirty tone it has. But I play live and the hiss it gives off when the gain is up really high will piss off the sound guys quite a bit. If I run a noise gate through the fx loop, will it gate the hiss coming from the head itself? The fx loop is a parallel loop. So Im not sure if that would do anything or not.
can you set it to serial?
yes it should, I run my decimator in the loop, and quiets down the preamp so you have no noise when you're not playing.