#1
i put on some distortion, and at frets <12 they sound fine, but for the higher frets they sound super bright and when i played a solo with mostly high frets, my frd was even wondering if i had any gain on the guitar. can someone tell what is going on?
#2
My guess would be the intonation or action is off but I'm not sure.
#3
Truss rod might need an adjustment
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#4
definitely sounds like a set-up issue. what happens when you play without gain? given that gain tends to mask detail, its better to examine issues on clean settings.

its probably an issue with neck relief.