I have the possibility of trading a cab away for a lefty les paul 100 and was wanting some opinions on playing a Les Paul reverse-style. Would it look too weird, would there be intonation problems, etc. Thanks in advance!
Not worth it.
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Other than the Special II the LP100 is the worst Epiphone made most likely in the LP family.
Moving on.....
What cab is it? That's not a good guitar, but to reverse it you'd need a new nut. The knobs might get in your way and you'd lose a lot of fret access.

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Your not Jimi, he did it out of necessity nothing else. And yes you will run into intonation issues, besides the fact it will have the fret access of an acoustic guitar.
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