Hi my bridge its an edge zero 2 and i wanna know if there is a problem if i lock them with the strings tuned and the locking nuts locked
??? sorry for my english
Pretty sure he's talking about the little screw within a screw on the posts for ibanez trems. Pretty sure I just failed at grammar too.

OP: If that is what you're talking about I'm almost sure you're supposed to set them without tension.