try it with only your guitar and see if the noise is still there.
Try a new cable.
start putting your pedals back in the chain 1 at a time to see if the problem shows up with a certain pedal or cable.

If you do all of this and you still get noise it is something in your amp.

It sounds like a bad cable or input in the signal chain from your description
2002 PRS CE22
2013 G&L ASAT Deluxe
2009 Epiphone G-400 (SH-4)
Marshall JCM2000 DSL100
Krank 1980 Jr 20watt
Krank Rev 4x12 (eminence V12)
GFS Greenie/Digitech Bad Monkey
Morley Bad Horsie 2
MXR Smart Gate
Last edited by Robbgnarly at Sep 28, 2013,