#1
My guitar is currently set up with .10-.46 D'Addario's, but was thinking of getting some slightly heavier strings. Will my guitar need to be set up again, or can I just throw them on as is?
Thanks!
#2
If you go heavier or lighter, you'll need to set up string height, truss rod, and intonation, as well as pickup height if you wish.
#4
Need is only if you notice what the differences are, honestly. The intonation is going to be off and the neck may move a bit, but it's not necessarily going to need adjustment.

Yes, it should be setup, but don't avoid trying different strings because you think you would be required to get a setup. You may hate the gauge, then you would need another setup to go back. I have had guitars go stupid from a gauge change and others that never changed a bit other than intonation being slightly off.