I'm not convinced there's any difference at all, especially with that sterile sounding distortion.

With a clean amp and a comparison between a metal alloy, nylon and timber-based materials I'd probably hear something, however minute.
"Air created the greenness. And once you've got something, that leads to otherness." - Karl Pilkington.
I've been using Clayton S-Stone 2.50 picks. I really like the tone and the grip is excellent.
Man, you guys stress way too hard over picks. They're just picks ffs. Find one that feels right in your fingers and just play. I've played gigs with clips off a bag of bread.
Gilchrist custom
Yamaha SBG500
Randall RM100 & RM20
Marshall JTM45 clone
Marshall JCM900 4102 (modded)
Marshall 18W clone
Fender 5F1 Champ clone
Atomic Amplifire
Marshall 1960A
Boss GT-100

Cathbard Amplification
My band