I want to make a cover of Biffy Clyro's Different People, but I can't seem to be able to find the right sound.. It's a very clean distortion, yet powerfull.
I own a Boss ME-50
Anyone any ideas on how I can get the sound or something close to it?
Had a listen, alot of that tone comes from playing a strat or similar single coil pickup'd guitar.

I don't own an ME-50 but you'll want a distortion with the lows cut and the treble boosted. (and a strat)

Hope this helps.
^ I'd suggest that plus just have a clean amp with the gain cranked plus maybe a tad of distortion pedal.
Gibson RD Silverburst w/ Lace Dissonant Aggressors (SOLD)
Electra Omega Prime Ceruse
Fender Franken-Jag Bass

Amps and the like:
Laney VH100R
Seismic Luke 2x12
Dunlop 105Q Wah
Gojira FX 808
Line 6 M9