I've been playing guitar for about 2 years now and don't know much about them on a technical side, I'm thinking about buying the Squier Simon Neil Biffy Clyro Strat in Fiesta Red but not sure if it would play Drop C and C# well, I use the Orange Micro Terror Head with the Orange PPC108 Micro Terror 1 x 8" Cabinet. any ideas?
Not really, lower tunings tend to sound better with humbuckers rather than single coils.

Saying that, i know Biffy use some low tunings for some songs.
I shouldn't post when drunk..

15 Jackson SLATHX-m 3-7 Slime green
Squier std tele (modded to hell)

Engl Powerball
Laney Ironheart 60h
Zilla Superfatboy 2x12 v30's