My current guitar has an E to E spacing of 2 3/16" and I just got a bridge and measured out the E to E spacing and it reads 2 1/16". Is that extra 1/8" really going to affect how I finger notes on the neck? I tried out another Tune o Matic a few weeks ago and the E to E was much tighter than this one. I currently have a Mustang bridge but want to shift to a Tune o Matic.
I doubt you'll notice anything. Usually the spacing at the nut is more of a deal than the bridge spacing. As long as the bridge fits you should be just fine.