I'm on an Epi LP, I use Ernie 11s and have some extra 10s. Any downside to switching between 10s and 11s every few weeks and besides intonation changes? Mainly talking about neck issues.
if you use the same tuning all the time probably not to much of an issue. you may have to adjust the neck occasionally.
I've often wondered this too, haven't had any problems but always wondered whether it would come back to bite me in the ass