I took the locking mechanism off the guitar and retuned the strings in the right order. I put it back on. When I plugged i into the amp there was lots of feedback. I turned the amp off and back on and that time their was no sound. I turned the amp on again and it worked. On some amp voices it is louder than it was before, on others softer. If the sound works at all their's nasty feedback. Sometimes the sound doesn't work. Could just retuning have moved the Floyd Rose and pinched the pickup connections?
Sounds like you have a ground issue possibly? Maybe the ground wire came off the trem when adjusting?