#3
Maybe a harmonizer for some parts, if it isn't a pre-recorded overdub. The guitar is distorted. That's pretty much all it could be.
Charvel So-Cal (SH6TB/N, killswitch), Jackson RR5FR (TB6/Jazz, Drop C). Joyo pxl pro.
Loop1=Crybaby from hell, Boss PS-5, Seymour Duncan 805 or Green Rhino, EQD Hoof or Earthbound Audio Super Collider. Loop 1 into ISP Decimator II.
Loop 2 (FX loop)-Line6 M9, TC Spark Mini. Loop 2 into mxr 10band. All into a Peavey Triple XXX 212, Ibanez IL15.
#4
At 0:24 you can see he's using a simulated signal chain.
Dry -> Filter/Equalizer -> Amp-Simulation (probably Overdriven Tube Amp) -> Delay -> Out.