Hi guitar people, first time posting here and I have a question about achieving good tone!

I'm playing a gibson 60's tribute les paul through a Roland Cube 40gx. I can get a really nice fat bluesy sound, but when i try to go for a more blues/rock sound a la gary moore it starts to sound very tinny and twangy on single note stuff and way too growly and unclear on chords?

I know you i cant sound exactly like someone with the setup i have but im just confused as to what i should change? Tried fiddling with tone,volume,bass,mid,treb,delay,reverb,gain the whole works but cant find that clear rock gain tone! Is it something wrong with my guitar/amp/leads? Sorry if this is vague! Any suggestions are appreciated