Just wondering what audio interface you guys use, as I've just ordered the Steinberg UR22 but am worried the latency will be high.
If you play guitar via your software and audio interface, do you get 'instant feedback' as if you were playing through an amplifier?

I use an M-Audio fast track into guitar rig 5.
I don't ever use monitoring, I record without it.
When I want to hear myself, I play through an amp.
Behringer UMC204HD into TH-3 and amplitube 4. love it. I had a Scarlett 2i4 but after the third one went south (started to make a lot of noise after 4-6 months) I took a chance on the berhringer. I've been really happy with it.
Ignoring my Pod HD500x, I run all my gear through a Novation Ultranova.
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Mah gear

Ibanez RG350mdx w/ SD TB-6
Ibanez RG7321 <3
Vyper 15
Ashdown EB 12-180 EVO II Combo

I use a Focusrite Scarlett 2i2 most of the time.

Sometimes I still use my old Line 6 GX though.
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I use a Focusrite Scarlett 6i6. Mostly got it for the SPDIF. Latency depends more on your computer than the interface in my experience. Even my old cheap Behringer interface doesn't have latency issues (the noise is ridiculous though in comparison with my 6i6).

No feedback here, unless I go really loud on my monitors.