KhawajaSahab either you are in desperate need of a proper setup (see a guitar tech), or its a problem with your technique (take lessons).
kentrock I'm going to agree it needs a setup. He may also have a wave in the neck. That happened to one of my guitars once. 
"It means a lot to me that my darkness can connect with your darkness and make it OK." - James Hetfield

Guitar: Ibanez S370
Seymour Duncan Pick ups
SH-4 JB (Neck)
Quarter Pound (Strat)
SH-6 Distortion (Bridge)

Peavey 6505 Mini Head
w/Peavey 112 Speaker cab (Celestion Greenback)

Boss NS-2
Boss DS-1