Neck pick up. Bass at max, treble at 7, mid at 5. Add some reverb. Maybe? Not to sure about the mesa.
My gear:

Gibson Gothic Flying V
Engl Screamer Combo
Maxon OD-9
Squier 10w amp
Okay, better, but not quite there... Its probably my pickups though..

Thanks man Lol at me trying it with no bass..
Neck pickup, a lot of mids, treble about halfway or lower, and bass mid way, and a lot of gain.
"Breathe, breathe in the air
Don't be afraid to care"

Fender Strat/Tokai LS80>few pedals>Orange Rocker 30
You won't if you don't have a mahogany guitar.

Besides that, ease up on the gain... A lot.
He who joyfully marches to music in rank and file has already earned my contempt.
He has been given a large brain by mistake, since for him the spinal cord would fully suffice.

Remember: A prudent question is one half of wisdom.