How do the changes in which pickups you want to work variat the sound of your guitar?

Like which ones would be good for a grungier sound or which ones would be better for a clean crisp solo?

In my opinoin only having the back pickup on gives the cleanest sound but any advice on pickups would be great since i highly lack knowledge in the technology aspect of the guitar.
Bridge pickups give you a dirtier tone, even more so if it's a humbucker. Neck pickups are generally for softer, smoother tones.
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