I want to know if anyone can tell me the perfect amp setting for the classic sweet child o mine riff to sound right, can anyone help???
Depends completely what amp you have.

Even if you get Slash's settings, you're not going to get that tone on a different amp.
"Breathe, breathe in the air
Don't be afraid to care"

Fender Strat/Tokai LS80>few pedals>Orange Rocker 30