Should I put it in line before or after my tube screamer and whatever else, or put it in the effects loop?

I'm running a loop through my digitech rp300 and i was looping delay but i'm not sure if i can use the compresser with it cause i'm not sure where the compressor goes.
i'd put it right in front of ur guitar...but thats just me
Signatures are a waste of space.
Mine is the first pedal in the chain. Certainly put it before any distortion/OD pedals.